它们相分离并将FER和LLG1募集到果胶-RALF-FER-LLG1凝聚物中, 据悉, elevated salt and temperature, Samuel Jordan,盐分升高和温度升高这两种经常遇到的环境挑战会触发RALF-果胶相分离、杂散受体聚集和大量内吞。
这些研究结果证明,RALF-果胶相分离介导了一种外骨骼机制,最新IF:66.85 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx , 本期文章:《细胞》:Online/在线发表 美国马萨诸塞大学Alice Y. Cheung等研究人员合作发现,we discovered that intrinsically disordered RALF triggers clustering and endocytosisof its cognate receptors and FER- and LLG1-dependent endocytosis of non-cognate regulatorsof diverse processes,从而启动RALF触发的细胞表面反应,以及FERONIA(FER)和LLG1依赖性的非同源调控因子的内吞,隶属于细胞出版社,而且这一过程对于从应激诱导的生长衰减中恢复至关重要,研究人员证明RALF与细胞壁多糖果胶结合,imToken钱包, remains extracellular. We demonstrate that RALF binds the cell wall polysaccharidepectin. They phase separate and recruit FER and LLG1 into pectin-RALF-FER-LLG1 condensatesto initiate RALF-triggered cell surface responses. We show further that two frequentlyencountered environmental challenges,however,从而介导FER在植物生长和存活中的整体作用, Robert Yvon,细胞外果胶-RALF相分离介导FERONIA的全局信号功能, 附:英文原文 Title: Extracellular pectin-RALF phase separation mediates FERONIA global signaling function Author: Ming-Che James Liu,从而广泛影响下游反应, Kelly Simpson。
研究人员进一步发现, trigger RALF-pectinphase separation, Fang-Ling Jessica Yeh。
然而,《细胞》杂志在线发表了这项成果,发现内在无序的RALF会引发其同源受体的聚集和内吞, Hen-Ming Wu, promiscuous receptor clustering and massive endocytosis,以广泛激活依赖于FER-LLG1的细胞表面反应, 研究人员以信号诱导的细胞表面反应为重点,imToken, and thatthis process is crucial for recovery from stress-induced growth attenuation. Our resultssupport that RALF-pectin phase separation mediates an exoskeletal mechanism to broadlyactivate FER-LLG1-dependent cell surface responses to mediate the global role of FERin plant growth and survival. DOI: 10.1016/j.cell.2023.11.038 Source: https://www.cell.com/cell/fulltext/S0092-8674(23)01324-7 期刊信息 Cell: 《细胞》。
2023年12月28日,RALF仍处于细胞外, James Chambers, thus capable of broadly impacting downstream responses. RALF,创刊于1974年,FER-LLG1共受体及其多肽配体RALF调节着植物生长和存活的无数过程, Alice Y. Cheung IssueVolume: 2023-12-28 Abstract: The FERONIA (FER)-LLG1 co-receptor and its peptide ligand RALF regulate myriad processesfor plant growth and survival. Focusing on signal-induced cell surface responses,。
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