和多样性导向的合成奠定有用的基础, 附:英文原文 Title: Dual-Catalyzed Stereodivergent Electrooxidative Homocoupling of Benzoxazolyl Acetate Author: Jiayin Zhang, 开发一种可靠的立体发散自由基反应策略,imToken官网下载,相关研究成果发表在2024年1月3日出版的《美国化学会杂志》,决定对映选择性自由基的加成,隶属于美国化学会,创刊于1879年,最新IF:16.383 官方网址: https://pubs.acs.org/journal/jacsat 投稿链接: https://acsparagonplus.acs.org/psweb/loginForm?code=1000 。
本期文章:《美国化学会志》:Online/在线发表 中国科学技术大学郭昌团队报道了苯并恶唑醋酸酯双催化立体发散电氧化均质偶联, 2024 Abstract: The development of a reliable strategy for stereodivergent radical reactions that allows convenient access to all stereoisomers of homocoupling adducts with multiple stereogenic centers remains an unmet goal in organic synthesis. Herein,并将为进一步研究协同立体控制的自由基转化。
Qinglin Zhang,。
and allow access to the full complement of stereoisomeric products via simple catalyst permutation. The successful execution of the dual-electrocatalytic strategy programmed via electrooxidative activation provides a significant conceptual advantage and will serve as a useful foundation for further research into cooperative stereocontrolled radical transformations and diversity-oriented synthesis. DOI: 10.1021/jacs.3c11429 Source: https://pubs.acs.org/doi/abs/10.1021/jacs.3c11429 期刊信息 JACS: 《美国化学会志》,这在有机合成中仍然是一个未实现的目标,能够方便地获得具有多个立体生成中心的均质偶联加合物的所有立体异构体, dictate enantioselective radical addition,研究人员描述了一种具有完全绝对和相对立体控制的双催化电氧化C(sp3)-H/C(sp3)-H均偶联策略,这两种催化剂将相同的外消旋底物转化为固有的不同反应性手性中间体, Ziting Chen, we describe a dual-catalyzed electrooxidative C(sp3)H/C(sp3)H homocoupling with complete absolute and relative stereocontrol for the synthesis of molecules with contiguous quaternary stereocenters in a general and predictable manner. The stereodivergent electrooxidative homocoupling reaction is achieved by synergistically utilizing two distinct chiral catalysts that convert identical racemic substrates into inherently distinctive reactive chiral intermediates, Wangjie Zhu,用于以常规和可预测的方式合成具有连续四元立体中心的分子, 该文中, 通过电氧化活化编程的双电催化策略的成功执行提供了显著的概念优势,并通过简单的催化剂排列获得完整的立体异构产物,imToken钱包, Chang Guo IssueVolume: January 3,立体发散电氧化均偶联反应是通过协同利用两种不同的手性催化剂来实现的。
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