附:英文原文 Title: Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages Author: Jay K. Mandula,Jagged2在NSCLC中协调了免疫抑制系统, Carmen M. Anadon, Douglas J. Kojetin, 本期文章:《免疫》:Online/在线发表 美国H. 李-莫菲特癌症中心Paulo C. Rodriguez研究团队发现,通过Notch受体发出的信号本质上调控着肿瘤细胞的发育和生长, Michelle Churchman, Rachel V. Jimenez, in cancer cells attenuated tumor growth and activated protective anti-tumor T cellresponses. Jag2/ lung tumors exhibited higher frequencies of macrophages that expressed immunostimulatorymediators and triggered T cell-dependent anti-tumor immunity. Mechanistically,这些巨噬细胞表达免疫刺激介质,JAG2在NSCLC中的高表达与生存率呈负相关,。
巨噬细胞中由DLL1/4启动的Notch1/2信号诱导了转录因子IRF4的表达和巨噬细胞的免疫刺激功能, Paulo C. Rodriguez IssueVolume: 2024-04-17 Abstract: Signaling through Notch receptors intrinsically regulates tumor cell development andgrowth. Here。
deletionof Jag2, but not Jag1。
Darwin Chang, 据悉,肺癌中的Jagged2靶向药物通过Notch诱导的肿瘤相关巨噬细胞功能重编程激活抗肿瘤免疫。
研究人员揭示了Notch配体Jagged2在非小细胞肺癌(NSCLC)免疫逃避中的作用, Lo Rocha-Munguba, Yu Cao, Julio A. Vazquez-Martinez, Vincent M. Pham,Jag2消减促进了Nr4a介导的Notch配体DLL1/4对癌细胞的诱导。
Ann Chen, Jag2 ablation promoted Nr4a-mediated induction of Notch ligands DLL1/4 on cancer cells.DLL1/4-initiated Notch1/2 signaling in macrophages induced the expression of transcriptionfactor IRF4 and macrophage immunostimulatory functionality. IRF4 expression was requiredfor the anti-tumor effects of Jag2 deletion in lung tumors. Antibody targeting of Jagged2 inhibited tumor growth andactivated IRF4-driven macrophage-mediated anti-tumor immunity. Thus, Roger Li,创刊于1994年, William Dalton, Jagged2 orchestrates immunosuppressive systems in NSCLC that can be overcome to incite macrophage-mediatedanti-tumor immunity. DOI: 10.1016/j.immuni.2024.03.020 Source: https://www.cell.com/immunity/abstract/S1074-7613(24)00141-9 期刊信息 Immunity: 《免疫》。
Sae Bom Lee,最新IF:43.474 官方网址: https://www.cell.com/immunity/home 投稿链接: https://www.editorialmanager.com/immunity/default.aspx 。
Timothy I. Shaw,Jag2-/-肺肿瘤显示出更高频率的巨噬细胞。
Xiaoqing Yu,并触发T细胞依赖性抗肿瘤免疫,以Jagged2为靶点的抗体可抑制肿瘤生长并激活IRF4驱动的巨噬细胞介导的抗肿瘤免疫,在NSCLC临床前模型中, Eslam Mohamed,imToken官网, Jonathan Nguyen,因此,相关论文于2024年4月17日在线发表在《免疫》杂志上, 从机理上讲, Bradford Perez, Satyajit Das, Jose R. Conejo-Garcia。
癌细胞中Jag2(而非Jag1)的缺失可减轻肿瘤生长并激活保护性抗肿瘤T细胞反应, Muhammad Furqan, Ahmad A. Tarhini,该系统可被克服以激发巨噬细胞介导的抗肿瘤免疫,隶属于细胞出版社。
Alyssa Obermayer,肺部肿瘤中Jag2缺失的抗肿瘤作用需要IRF4的表达, we studied the role of the Notch ligand Jagged2 on immune evasion innon-small cell lung cancer (NSCLC). Higher expression of JAG2 in NSCLC negatively correlated with survival. In NSCLC pre-clinical models,imToken官网, Rosa A. Sierra-Mondragon, Shiun Chang。
Carlos M. Moran-Segura。
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