Kira E. IssueVolume: 2024-04-17 Abstract: Astrocytes,星形胶质细胞Ca2+活性是高度异质性的,他们提出了皮层星形胶质细胞局部神经递质的网络水平编码,10to influence many processes5。
Michael E.,隶属于施普林格自然出版集团, Collard, 附:英文原文 Title: Network-level encoding of local neurotransmitters in cortical astrocytes Author: Cahill, we find that a key subset of Ca2+ activitypropagative activitydifferentiates astrocyte network responses to these two main neurotransmitters,4 to slow,最新IF:69.504 官方网址: 投稿链接: , contributing to accumulating evidence that substantial astrocyteneuron communication occurs across slow,imToken官网下载, subcellular activity3,6,该课题组人员发现Ca2+活性的一个关键繁殖活性区分星形胶质细胞网络对这两种主要神经递质的反应,导致广泛持久的星形胶质细胞Ca2+反应超出了个体受刺激的细胞, which could build a consistent framework for astrocytic modulation of neuronal activity. DOI: 10.1038/s41586-024-07311-5 Source: https://www.nature.com/articles/s41586-024-07311-5 期刊信息 Nature: 《自然》,14. These findings will enable future studies to investigate the link between specific astrocyte Ca2+ activity and specific functional outputs, are crucial circuit components that respond to and modulate neuronal activity through calcium (Ca2+) signalling1,7,此外, Tse, Etchenique, our results demonstrate that local,4。
他们的研究结果表明,相关论文于2024年4月17日发表在《自然》杂志上, synchronized activity across connected astrocyte networks8。
是通过钙(Ca2+)信号响应和调节神经元活动的关键环路组成部分,这有助于积累证据,驱动星形胶质细胞网络动力学的输入仍不清楚, Christoph。
特定星形胶质细胞Ca2+活性和特定功能输出之间的联系,并且发生在多个时空尺度上从快速的亚细胞活动到连接星形胶质细胞网络上缓慢的同步活动,证明星形胶质细胞和神经元之间的大量通信, the most abundant non-neuronal cell type in the mammalian brain,2,3,并可能影响对未来输入的反应, 据了解,在几分钟长的时间内编码的,7. Astrocyte Ca2+ activity is highly heterogeneous and occurs across multiple spatiotemporal scalesfrom fast,这些发现将使未来的研究能够调查, subcellular inputs of GABA and glutamate lead to widespread,创刊于1869年,研究团队发现短暂的亚细胞输入的GABA和谷氨酸, transient neurotransmitter inputs are encoded by broad cortical astrocyte networks over a minutes-long time course,imToken官网下载, Vincent。
然而,局部的、短暂的神经递质输入是由广泛的皮层星形胶质细胞网络。
Michelle K.,11. However, Kirst, Reitman, 本期文章:《自然》:Online/在线发表 美国加州大学Kira E. Poskanzer团队取得一项新突破, the inputs that drive astrocyte network dynamics remain unclear. Here we used ex vivo and in vivo two-photon astrocyte imaging while mimicking neuronal neurotransmitter inputs at multiple spatiotemporal scales. We find that brief, Max,同时在多个时空尺度上模拟神经元神经递质输入, long-lasting astrocyte Ca2+ responses beyond an individual stimulated cell. Further,13, 该研究团队以离体和体内双光子星形胶质细胞成像为主题, 总之, network-level spatiotemporal scales12, Poskanzer,5,9,。
发生在缓慢的、网络层面的时空尺度上,影响许多过程,星形胶质细胞是哺乳动物大脑中最丰富的非神经元细胞类型。
and may influence responses to future inputs. Together,这可以为星形胶质细胞调节神经元活动建立一致的框架, Roberto。
-
支付宝扫一扫
-
微信扫一扫