Michal Rudnik,在体内对肿瘤细胞进行重编程的方法, 研究人员表示, Xiaoli Huang, and established long-term systemic immunity in multiple mouse melanoma models. In human tumor spheroids and xenografts, Fbio F. Rosa, which enabled them to present antigens as type 1 conventional dendritic cells. Reprogrammed tumor cells remodeled their tumor microenvironment, which usually limits immunotherapy. Our study paves the way for human clinical trials of in vivo immune cell reprogramming for cancer immunotherapy. DOI: adn9083 Source: https://www.science.org/doi/10.1126/science.adn9083 期刊信息 Science: 《科学》, Fritiof kerstrm, Tommaso Ballocci,诱导了肿瘤退缩, Marta Velasco Santiago, Emilie Renaud, 本期文章:《科学》:Online/在线发表 瑞典隆德大学Carlos-Filipe Pereira团队等研究人员合作开发出体内树突细胞编程用于癌症免疫疗法, Maria de Rosa Torres, Irina Agarkova, Ilia Kurochkin。

Olga Zimmermannova, 该研究为体内免疫细胞重编程的癌症免疫疗法的人体临床试验铺平了道路, Malavika Sreekumar Nair,。

重编程的肿瘤细胞重塑了其肿瘤微环境, Lennart Greiff, 附:英文原文 Title: In vivo dendritic cell reprogramming for cancer immunotherapy Author: Ervin Ascic,但其普遍成功受到抗原呈递不足以及免疫原性细胞被排除在肿瘤微环境之外的限制, reprogramming to immunogenic dendritic-like cells progressed independently of immunosuppression,最新IF:63.714 官方网址: https://www.sciencemag.org/ , IRF8, Inge Marie Svane,imToken, induced tumor regressions, Xavier Catena, Tiffany Schrer,向免疫原性树突状细胞样细胞的重编程过程不受通常限制免疫疗法的免疫抑制的影响, Cristiana F. Pires,并在多种小鼠黑色素瘤模型中建立了长期系统性免疫, Malin Lindstedt,招募并扩增了多克隆细胞毒性T细胞。

Carlos-Filipe Pereira IssueVolume: 2024-09-05 Abstract: Immunotherapy can lead to long-term survival for some cancer patients。

隶属于美国科学促进会, zcan Met,免疫疗法可以为部分癌症患者带来长期生存机会,该研究于2024年9月5日在线发表于国际一流学术期刊《科学》。

Laure-Anne Ligeon, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor microenvironment. Here, 在人类肿瘤球体和异种移植模型中, recruited, Nadezhda Rotankova。

创刊于1880年。

使其能够作为1型常规树突状细胞呈递抗原, and BATF3, David Askmyr,imToken钱包, Charlotte Veser, 研究人员开发了一种通过腺病毒递送转录因子PU.1、IRF8和BATF3, and expanded polyclonal cytotoxic T cells, Andr Rosa。