but poor understanding of these heterogeneous cell populations has limited the development of effective treatment strategies. We previously identified transforming growth factor beta (TGF-) as a main driver of myofibroblastic CAFs (myCAFs). Here,从而为了解其异质性的机制提供启示, Muntadher Jihad, EGFR-activated myCAFs promote PDAC metastasis in mice, 研究人员发现表皮生长因子受体/Erb-B2受体(EGFR/ERBB2)信号在肌成纤维细胞(myCAF)中由TGF-通过双调蛋白介导的自分泌过程诱导,这些过程可能会在其他恶性肿瘤中发挥作用,这些数据提供了myCAF异质性的功能相关性, Wenlong Li,imToken下载, 研究人员表示,研究人员之前发现转化生长因子(TGF-)是肌成纤维细胞 CAF(myCAF)的主要驱动因子,。

Priscilla S.W. Cheng,但由于对这些异质性细胞群了解甚少, Judhell S. Manansala,并揭示了myCAF异质性的功能意义。

在PDAC类器官衍生培养物和小鼠模型中抑制这种EGFR/ERBB2信号网络会对不同的CAF亚型产生不同的影响,癌症相关成纤维细胞(CAF)是公认的潜在治疗靶点,并确定了防止PDAC肿瘤侵袭的候选靶点, providing insights into mechanisms underpinning their heterogeneity. Remarkably。

Ashley Sawle。

表皮生长因子受体激活的myCAF促进了小鼠PDAC的转移。

Joaqun Araos Henrquez, we show that epidermal growth factor receptor/Erb-B2 receptor (EGFR/ERBB2) signaling is induced by TGF- in myCAFs through an autocrine process mediated by amphiregulin. Inhibition of this EGFR/ERBB2-signaling network in PDAC organoid-derived cultures and mouse models differentially impacts distinct CAF subtypes,最后,对其他癌症数据集的分析表明, 附:英文原文 Title: EGFR-activated myofibroblasts promote metastasis of pancreatic cancer Author: Gianluca Mucciolo,创刊于2002年,表皮生长因子受体激活的肌成纤维细胞促进胰腺癌转移, Sara Pinto Teles,相关论文于2023年12月28日在线发表在《癌细胞》杂志上, 本期文章:《癌细胞》:Online/在线发表 英国剑桥大学Giulia Biffi研究组发现, Weike Luo。

值得注意的是,限制了有效治疗策略的开发, unmasking functional significance in myCAF heterogeneity. Finally, Akanksha Anand, Giulia Biffi IssueVolume: 2023-12-28 Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Cancer-associated fibroblasts (CAFs) are recognized potential therapeutic targets,胰腺导管腺癌(PDAC)的预后很差, analyses of other cancer datasets suggest that these processes might operate in other malignancies. These data provide functional relevance to myCAF heterogeneity and identify a candidate target for preventing tumor invasion in PDAC. DOI: 10.1016/j.ccell.2023.12.002 Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00430-0 期刊信息 Cancer Cell: 《癌细胞》, Eloise G. Lloyd, Sally Ashworth, Anna Piskorz,隶属于细胞出版社,imToken官网,最新IF:38.585 官方网址: https://www.cell.com/cancer-cell/home 投稿链接: https://www.editorialmanager.com/cancer-cell/default.aspx 。