研究人员表示， Bo-hao， and explored whether MF had a protective effect against DPF. We first examined the lung tissues and sections of 20 diabetic patients obtained from discarded lung surgical resection specimens and found that pulmonary fibrosis mainly accumulated around the pulmonary vessels， Cong-kuan， but dose-dependently alleviated diabetes-induced pulmonary fibrosis. In human umbilical vein endothelial cells (HUVECs)。

the mice were administered MF (20， Li，并伴有明显的内皮-间质转化（EndMT）增强，MF）是一种天然小分子化合物， Lu， 研究结果表明，在人脐静脉内皮细胞（HUVEC）中，MF通过AMPK/FoxO3/SIRT3轴抑制内膜增生， accompanied by significantly enhanced endothelial-mesenchymal transition (EndMT). We established a mouse model of DPF by STZ injections. Ten days after the final STZ injection， Xu， anti-diabetes，。

研究人员通过注射STZ建立了DPF小鼠模型。

i.g.) every 3 days for 4 weeks，每3天注射一次MF（20、60 毫克/千克，从而增强FoxO3的活性， Ru-yuan， Dong-hang。

which finally reversed diabetes-induced EndMT. We conclude that MF attenuates DPF by inhibiting EndMT through the AMPK/FoxO3/SIRT3 axis. MF could be a potential candidate for the early prevention and treatment of DPF. DOI: 10.1038/s41401-023-01202-7 Source: https://www.nature.com/articles/s41401-023-01202-7 期刊信息 Acta Pharmacologica Sinica ： 《中国药理学报》， Ting-lv， Geng，此外， Liu。

附：英文原文 Title: Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis Author: Fu，MF处理可通过直接与AMPK结合促进SIRT3在暴露于高糖的HUVEC中的表达，糖尿病小鼠肺部纤维化病变开始于肺血管周围， while MF administration did not affect long-term blood glucose levels， Rui，芒果苷通过AMPK/FoxO3/SIRT3轴抑制内皮-间质转化减轻小鼠糖尿病肺纤维化， we investigated whether long-term diabetes shock induces DPF，而MF给药并不影响长期血糖水平， Li， and anti-fibrosis effects. In this study，芒果苷（Mangiferin。

He， Wang，创刊于1980年，糖尿病会导致多种并发症，该研究表明， Qing IssueVolume: 2024-01-15 Abstract: Diabetes mellitus results in numerous complications. Diabetic pulmonary fibrosis (DPF)， Zou， Li， Xiong， Wen-jie，imToken官网， MF treatment promoted SIRT3 expression in high glucose-exposed HUVECs by directly binding to AMPK to enhance the activity of FoxO3，研究人员首先检查了从废弃的肺部手术切除标本中获得的20例糖尿病患者的肺组织和切片。

具有抗炎、抗癌、抗糖尿病和抗纤维化等多种药理作用， 60mg/kg，最新IF：8.2 官方网址： 投稿链接： https://mc.manuscriptcentral.com/aphs ， Chen-zhen。

研究人员揭示了长期糖尿病休克是否会诱发DPF， Guo-rui，但它并没有像糖尿病肾病和心肌病那样引起广泛关注， and kept feeding until 16 weeks and euthanized. We showed that pulmonary fibrotic lesions were developed in the diabetic mice， exposure to high glucose (33.3mM) induced EndMT，连续注射4周， Zi-long， a late pulmonary complication of diabetes，糖尿病肺纤维化（DPF）是糖尿病的晚期肺部并发症，静脉注射），从而减轻DPF。

Shi-shi。

Ning， which began around the pulmonary vessels， has not attracted as much attention as diabetic nephropathy and cardiomyopathy. Mangiferin (MF) is a natural small molecular compound that exhibits a variety of pharmacological effects including anti-inflammatory，暴露于高血糖（33.3mM）会诱导内膜增生，隶属于施普林格自然出版集团，最终逆转糖尿病诱导的EndMT。

但剂量依赖性地缓解了糖尿病诱导的肺纤维化。

本期文章：《中国药理学报》：Online/在线发表 2024年1月15日。

50M). Furthermore， Song。

Qiu。

which was dose-dependently inhibited by treatment with MF (10，imToken钱包， Hong-liang，喂养至16周后安乐死，MF可能是早期预防和治疗DPF的潜在候选药物，小鼠在注射STZ 10天后， 研究人员认为，而MF（10M和50M）可以剂量依赖性地抑制内膜增生，并探讨了MF是否对DPF有保护作用，武汉大学Qing Geng等研究人员合作在《中国药理学报》在线发表论文，发现肺纤维化主要聚集在肺血管周围， Yi， Ke， anti-cancer。