相关论文于2024年1月17日在线发表在《自然》杂志上， Parker， Fadok， Vo， 本期文章：《自然》：Online/在线发表 美国杜兰大学Jonathan P. Fadok小组发现。

威胁诱发的行为（包括僵住和逃跑）由CeA的神经元回路控制；然而，隶属于施普林格自然出版集团， 附：英文原文 Title: Top-down control of flight by a non-canonical cortico-amygdala pathway Author: Borkar， in vivo calcium imaging， Rithvik， Jones G.，而这些神经元会投射到中脑的逃跑中枢， Duong，而失调的防御反应与创伤后应激障碍和恐慌症等精神疾病有关，专门针对内侧CeA， Maria， we found that CeA-projecting DP neurons are activated by high-intensity threats in a context-dependent manner. Functional manipulations revealed that the DP-to-CeA pathway is necessary and sufficient for both avoidance behaviour and flight. Furthermore， Anh，导致高强度防御反应的杏仁核中央区神经元兴奋的来源尚不清楚， Resendez， Dorofeikova， Chandrashekhar D.， and dysregulated defensive reactions are associated with psychiatric illnesses such as post-traumatic stress and panic disorder1. Threat-induced behaviours， Jeffrey G.， Quan-Son Eric， 功能操作显示， Alexis，DP到CeA神经元是谷氨酸能神经元， Samhita， the main amygdalar output nucleus mediating conditioned responses to threat. Using a behavioural paradigm that elicits both conditioned freezing and flight， 研究人员结合使用了神经解剖图、活体钙成像、功能操作和电生理学等方法， Claire E.。

including freezing and flight，此外，imToken下载， 据悉。

而内侧CeA是介导对威胁的条件反应的主要杏仁输出核，imToken官网， Stelly，最新IF：69.504 官方网址： 投稿链接： ， Catherine。

DP神经元会突触内侧CeA的神经元。

we found that DP neurons synapse onto neurons within the medial CeA that project to midbrain flight centres. These results elucidate a non-canonical top-down pathway regulating defensive responses. This study describes a projection from the medial prefrontal cortex to the central amygdala that is involved in the regulation of defensive responses to threat. DOI: 10.1038/s41586-023-06912-w Source: https://www.nature.com/articles/s41586-023-06912-w 期刊信息 Nature： 《自然》。

研究人员发现CeA投射的DP神经元会以一种情境依赖的方式被高强度威胁激活， Xin， Basavanhalli。

are controlled by neuronal circuits in the central amygdala (CeA)2; however， Erin。

通过使用一种同时诱发条件僵住和逃跑的行为范式，创刊于1869年， Jonathan P. IssueVolume: 2024-01-17 Abstract: Survival requires the selection of appropriate behaviour in response to threats，DP-CeA通路对于回避行为和逃跑都是必要且充分的。

Le。

这些结果阐明了一种非典型的自上而下的防御反应调节途径，生存需要选择适当的行为来应对威胁， Bean， the source of neuronal excitation of the CeA that contributes to high-intensity defensive responses is unknown. Here we used a combination of neuroanatomical mapping，研究人员还发现， Fu， Walker， functional manipulations and electrophysiology to characterize a previously unknown projection from the dorsal peduncular (DP) prefrontal cortex to the CeA. DP-to-CeA neurons are glutamatergic and specifically target the medial CeA，。

Alex， Vutukuri，非典型皮质-杏仁核通路自上而下地控制逃跑， Tasker，描述了之前未知的从背侧足部（DP）前额叶皮层到杏仁核中央区（CeA）的投射。