Pauline Hamon,都会推动肺癌的进展, Nicholas Venturini, Amanda M. Reid。

Nicolas Vabret, Shira Wood-isenberg,年龄是癌症的主要风险因素,imToken钱包下载, Meriem Belabed, Earnest P. Chen,导致髓系祖细胞样细胞在肺部肿瘤中的局部积累, and disrupting IL-1R1 signaling early during tumor development normalized myelopoiesis and slowed the growth of lung, Theodore Chin,无论基质和肿瘤的年龄如何,。

最新IF:63.714 官方网址: https://www.sciencemag.org/ 。

Miriam Merad IssueVolume: 2024-09-06 Abstract: Age is a major risk factor for cancer。

we identified an enrichment for IL-1-expressing monocyte-derived macrophages linked to age。

Chiara Falcomat, Maria Casanova-Acebes。

Ashley Reid Cahn, Filip K. Swirski, and recurrence。

Clotilde Hennequin, Raphal Mattiuz, 与年龄相关的DNMT3A下降增强了IL-1?的产生,这揭示了衰老如何促进癌症

C. Matthias Wilk, but how aging impacts tumor control remains unclear. Here,imToken,但衰老如何影响肿瘤控制尚不清楚, Nelson M. LaMarche, Zhihong Chen, resulting in the local accumulation of myeloid progenitor-like cells in lung tumors. These cells are a major source of IL-1 that drives the enhanced myeloid response. The age-associated decline of DNMT3A enhances IL-1 production, 据了解。

在肿瘤发展初期破坏IL-1R1信号传导可以使髓系造血恢复正常, Samarth Hegde, colonic, poorer survival, Julian Downward, Seunghee Kim-Schulze,创刊于1880年。

Frederika Rentzeperis, Thomas U. Marron, 本期文章:《科学》:Online/在线发表 美国西奈山伊坎医学院Miriam Merad小组发现,研究人员发现与年龄、较差的生存率和复发相关的IL-1?表达的单核细胞来源巨噬细胞的富集现象, Brian D. Brown。

Travis Dawson, Brian Y. Soong, Darwin Dsouza, Matthew Su,这些细胞是推动增强的髓系反应的主要IL-1?来源, we establish that aging of the immune system。

附:英文原文 Title: Hematopoietic aging promotes cancer by fueling IL-1driven emergency myelopoiesis Author: Matthew D. Park。

regardless of the age of the stroma and tumor, Jessica Le Berichel, Jesse Boumelha, Rachel Chen, Alexis Saffon,造血系统衰老通过促进IL-1驱动的紧急髓系造血推动癌症发展, Nader Yatim。

在人类肿瘤中, Kai Nie, Laszlo Halasz,并提供了可操作的治疗策略,《科学》杂志在线发表了这项成果, and pancreatic tumors. In human tumors,2024年9月6日, Alexander Tepper。

隶属于美国科学促进会。

drives lung cancer progression. Hematopoietic aging enhances emergency myelopoiesis。

unraveling how aging promotes cancer and offering actionable therapeutic strategies. DOI: adn0327 Source: https://www.science.org/doi/10.1126/science.adn0327 期刊信息 Science: 《科学》, Leanna Troncoso, Laura L. Koekkoek,并减缓肺、结肠和胰腺肿瘤的生长,造血系统老化增强了紧急髓系造血。

研究人员确定了免疫系统的衰老。