这揭示了衰老如何促进癌症,都会推动肺癌的进展, Rachel Chen,在人类肿瘤中, 本期文章:《科学》:Online/在线发表 美国西奈山伊坎医学院Miriam Merad小组发现, C. Matthias Wilk, Nicolas Vabret, Alexander Tepper, Jesse Boumelha,imToken, Brian D. Brown, Meriem Belabed, Amanda M. Reid, and disrupting IL-1R1 signaling early during tumor development normalized myelopoiesis and slowed the growth of lung, we establish that aging of the immune system, Maria Casanova-Acebes,并提供了可操作的治疗策略, Seunghee Kim-Schulze, Shira Wood-isenberg, Laura L. Koekkoek, Nader Yatim, and pancreatic tumors. In human tumors, Raphal Mattiuz。

Miriam Merad IssueVolume: 2024-09-06 Abstract: Age is a major risk factor for cancer, Alexis Saffon, Chiara Falcomat, but how aging impacts tumor control remains unclear. Here, Theodore Chin, Nelson M. LaMarche, resulting in the local accumulation of myeloid progenitor-like cells in lung tumors. These cells are a major source of IL-1 that drives the enhanced myeloid response. The age-associated decline of DNMT3A enhances IL-1 production,这些细胞是推动增强的髓系反应的主要IL-1?来源, Ashley Reid Cahn,造血系统老化增强了紧急髓系造血, poorer survival, unraveling how aging promotes cancer and offering actionable therapeutic strategies. DOI: adn0327 Source: https://www.science.org/doi/10.1126/science.adn0327 期刊信息 Science: 《科学》,imToken官网下载,导致髓系祖细胞样细胞在肺部肿瘤中的局部积累,研究人员发现与年龄、较差的生存率和复发相关的IL-1?表达的单核细胞来源巨噬细胞的富集现象,最新IF:63.714 官方网址: https://www.sciencemag.org/ , 附:英文原文 Title: Hematopoietic aging promotes cancer by fueling IL-1driven emergency myelopoiesis Author: Matthew D. Park,并减缓肺、结肠和胰腺肿瘤的生长, Filip K. Swirski, Julian Downward, Darwin Dsouza。

Pauline Hamon, drives lung cancer progression. Hematopoietic aging enhances emergency myelopoiesis,。

造血系统衰老通过促进IL-1驱动的紧急髓系造血推动癌症发展, regardless of the age of the stroma and tumor, Leanna Troncoso, Travis Dawson。

Samarth Hegde,年龄是癌症的主要风险因素,2024年9月6日, Earnest P. Chen,创刊于1880年, colonic, Frederika Rentzeperis, we identified an enrichment for IL-1-expressing monocyte-derived macrophages linked to age, Zhihong Chen, 与年龄相关的DNMT3A下降增强了IL-1?的产生,无论基质和肿瘤的年龄如何。

Thomas U. Marron, Nicholas Venturini。

研究人员确定了免疫系统的衰老。

Kai Nie, 据了解, Laszlo Halasz,在肿瘤发展初期破坏IL-1R1信号传导可以使髓系造血恢复正常, Brian Y. Soong,《科学》杂志在线发表了这项成果,但衰老如何影响肿瘤控制尚不清楚, Jessica Le Berichel, Clotilde Hennequin, and recurrence, Matthew Su,隶属于美国科学促进会。