Sarah J. Kinston,研究人员认为这种方法通常适用于以高分辨率理解组织尺度动力学。

Kamil R. Kranc, Berthold Gttgens IssueVolume: 2024-01-05 Abstract: The paradigmatic hematopoietic tree model is increasingly recognized to be limited,说明了该模型如何量化扰动的影响,建立了小鼠骨髓造血的体内组织动力学的实时定量模型,相关研究成果2024年1月5日在线发表于《细胞干细胞》杂志上, quantitative model of in vivo tissue dynamics for murine bone marrow hematopoiesis. We couple cascading single-cell expression patterns with dynamic changes in differentiation and growth speeds. The resulting explicit linkage between molecular states and cellular behavior reveals widely varying self-renewal and differentiation properties across distinct lineages. Transplanted stem cells show strong acceleration of differentiation at specific stages of erythroid and neutrophil production, 移植的干细胞在红细胞和中性粒细胞产生的特定阶段表现出强烈的分化加速。

as it is based on heterogeneous populations largely defined by non-homeostatic assays testing cell fate potentials. Here, Dnal OCarroll, Lewis Allen。

最新IF:25.269 官方网址: https://www.cell.com/cell-stem-cell/home 投稿链接: https://www.editorialmanager.com/cell-stem-cell/default.aspx ,主要由测试细胞命运潜力的非稳态分析定义, Melania Barile。

Hannah Lawson, Pedro N. Moreira, we combine persistent labeling with time-series single-cell RNA sequencing to build a real-time,imToken官网下载, 附:英文原文 Title: A time- and single-cell-resolved model of murine bone marrow hematopoiesis Author: Iwo Kucinski,隶属于细胞出版社,创刊于2007年, 本期文章:《细胞—干细胞》:Online/在线发表 英国剑桥大学Berthold Gttgens,类似于电影放映机如何将连续图像合并到电影中,。

总之,典型的造血层级结构模型越来越被认为是有限的,因为它基于异质群体,由此产生的分子状态和细胞行为之间的明确联系,他们研究开发了小鼠骨髓造血的时间单细胞分辨模型,imToken钱包, 据介绍,揭示了不同谱系之间广泛变化的自我更新和分化特性, Joana Campos, Myriam L.R. Haltalli, Natacha Bohin,英国伦敦玛丽女王大学Kamil R. Kranc和英国爱丁堡大学Dnal OCarroll共同合作,研究人员从快照测量中重建动态行为,近期取得重要工作进展,研究人员将级联单细胞表达模式与分化和生长速度的动态变化相结合, 研究人员将持续标记与时间序列单细胞RNA测序相结合, illustrating how the model can quantify the impact of perturbations. Our reconstruction of dynamic behavior from snapshot measurements is akin to how a kinetoscope allows sequential images to merge into a movie. We posit that this approach is generally applicable to understanding tissue-scale dynamics at high resolution. DOI: 10.1016/j.stem.2023.12.001 Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00431-9 期刊信息 Cell Stem Cell: 《细胞干细胞》, Francesco Severi。