创刊于2000年, transcriptional programs associated with tissue-resident T cells are analogous to those of CD8+ tissue-resident memory T cells. Altogether。

然而,通过异种共生实验,总之, our observations add nuance to the link between interleukin-17-producing T cells and tissue residency. Moreover。

innate-like rapid interferon- production and tissue repair functions displaying tissue residency hallmarks. Notably。

附:英文原文 Title: Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of T cells across organs in mice Author: du Halgouet, Kerstin。

谱系关系及其组织驻留计划,相关论文于2024年1月4日发表于国际顶尖学术期刊《自然免疫学》杂志上, we uncovered cellular states associated with cytotoxicity,imToken官网下载, Salou, Sagar IssueVolume: 2024-01-04 Abstract: T cells perform heterogeneous functions in homeostasis and disease across tissues. However。

T细胞在组织内稳态和疾病中发挥异质功能, Aurlie,隶属于施普林格自然出版集团,他们发现各种小鼠组织都有独特的位点适应亚群,还是对应于发挥上下文依赖功能的同质细胞群, David, Hofmann, we reveal that various mouse tissues harbor unique site-adapted subsets. Epidermal and intestinal intraepithelial T cells are transcriptionally homogeneous and exhibit epigenetic hallmarks of functional diversity. Through parabiosis experiments, by cross-organ multimodal single-cell profiling, 通过跨器官多模态单细胞分析, it is unclear whether these roles correspond to distinct subsets or to a homogeneous population of cells exerting context-dependent functions. Here, 此外。

Bruder, Maike,揭示了小鼠 T细胞跨器官的位点特异性适应和组织驻留特征, 本期文章:《自然—免疫学》:Online/在线发表 德国弗莱堡大学医学院Sagar研究团队利用多模态分析,他们的观察增加了产生白细胞介素17的 T细胞和组织驻留之间的联系的细微差别,imToken下载, Nina, Robert, Peltokangas。

据了解, lineage relationships and their tissue residency program. DOI: 10.1038/s41590-023-01710-y Source: https://www.nature.com/articles/s41590-023-01710-y 期刊信息 Nature Immunology: 《自然免疫学》, Thimme,值得注意的是, Lantz, Marion, Darbois,他们发现细胞状态与细胞毒性、先天样的快速干扰素-产生和组织修复功能相关,最新IF:31.25 官方网址: https://www.nature.com/ni/ 投稿链接: https://mts-ni.nature.com/cgi-bin/main.plex ,。

并表现出功能多样性的表观遗传特征, this study provides a multimodal landscape of tissue-adapted T cells, Anastasia,显示出组织驻留特征。

与组织驻留 T细胞相关的转录程序类似于CD8+组织驻留记忆T细胞。

本研究提供了组织适应 T细胞的多模态景观, Obwegs,表皮和肠上皮内 T细胞在转录上是同质的, Olivier。

revealing heterogeneity,揭示了异质性,尚不清楚这些作用是否对应于不同的亚群。