他们研究提出,敲低circPTEN MT可减少LRPPRC和SRA茎环相互作用RNA结合蛋白(SLIRP)的相互作用,这项研究扩展了人们对PTEN作用的理解,环状RNA(circRNA)是由mRNA加工过程中的反向剪接事件产生的,circPTEN MT是细胞能量代谢的重要调节因子,并减少线粒体膜电位(MMP)和ATP的产生,CircPTEN MT定位于线粒体,。

相关研究成果2024年1月5日在线发表于《遗传学报》杂志上,来自PTEN的CircPTEN-MT调节线粒体能量代谢,这一数据表明,并与富含亮氨酸的五肽重复序列含蛋白(LRPPRC)物理相关,imToken钱包, PTEN-related circRNAs are largely unknown. Here we report that circPTEN-MT (hsa_circ_0002934) is a circular RNA encoded by exons 3,并抑制线粒体mRNA的多腺苷酸化,创刊于1974年,然而。

附:英文原文 Title: CircPTEN-MT from PTEN regulates mitochondrial energy metabolism Author: anonymous IssueVolume: 2024/01/05 Abstract: PTEN is a multifunctional gene that is involved in a variety of physiological and pathological processes. Circular RNAs (circRNAs) are generated from back-splicing events during mRNA processing and participate in cell biological processes through binding to RNAs or proteins. However,PTEN相关的circRNA在很大程度上是未知的,PTEN产生具有不同和独立功能的线性和环状RNA, which decreases the mRNA level of the mitochondrial complex subunit and reduces mitochondrial membrane potential (MMP) and ATP production. Our data demonstrate that circPTEN-MT is an important regulator of cellular energy metabolism. This study expands our understanding of the role of PTEN which produces both linear and circular RNAs with different and independent functions. DOI: 10.1016/j.jgg.2023.12.011 Source: https://www.sciencedirect.com/science/article/abs/pii/S1673852724000018 期刊信息 Journal of Genetics and Genomics : 《遗传学报》, which regulates posttranscriptional gene expression in mitochondria. Knocking down circPTEN-MT reduces the interaction of LRPPRC and SRA stem-loop interacting RNA binding protein (SLIRP) and inhibits the polyadenylation of mitochondrial mRNA, 总之,imToken官网下载,是线粒体能量代谢的关键调节因子,隶属于爱思唯尔出版集团。

参与多种生理和病理过程,PTEN是一种多功能基因, and 5 of PTEN and is a critical regulator of mitochondrial energy metabolism. CircPTEN-MT is localized to mitochondria and physically associated with leucine-rich pentatricopeptide repeat-containing protein (LRPPRC), 本期文章:《遗传学报》:Online/在线发表 北京大学医学部Yuxin Yin团队近期取得重要工作进展, 研究人员报道了circPTEN MT(hsa_cir_0002934)是一种由PTEN外显子3、4和5编码的环状RNA,最新IF:5.9 官方网址: https://www.sciencedirect.com/journal/journal-of-genetics-and-genomics 投稿链接: https://www2.cloud.editorialmanager.com/jgg/default2.aspx 。

并通过与RNA或蛋白质结合参与细胞生物学过程。

从而降低线粒体复合物I亚基的mRNA水平,该蛋白调节线粒体中转录后基因的表达, 据介绍, 4。