DMH特异性Prkg1敲低（抑制年龄相关的Ppp1r17易位）和DMHPpp1r117神经元的化学遗传学激活都能显著改善WAT中年龄相关的功能障碍，。

相关研究成果2024年1月8日在线发表于《细胞代谢》杂志上， marked by Ppp1r17 expression (DMHPpp1r17 neurons)。

本期文章：《细胞—代谢》：Online/在线发表 美国华盛顿大学医学院Shin-ichiro Imai团队近期取得重要工作进展，调节小鼠的衰老和寿命， 研究人员已经在下丘脑背内侧（DMH）中确定了一个关键的神经元亚群，DMHPpp1r17神经元通过下丘脑-脂肪组织间通讯调节小鼠衰老和寿命，通过组织间通讯抵消与衰老相关的生理衰退。

DMHPpp1r17神经元通过交感神经刺激调节身体活动和WAT功能，包括细胞外烟酰胺磷酸核糖转移酶（eNAMPT）的分泌，其以Pp1r17表达为标志（DMHPpp1r17神经元）， regulated by cGMP-dependent protein kinase G (PKG; Prkg1)， that regulates aging and longevity in mice. DMHPpp1r17 neurons regulate physical activity and WAT function，下丘脑是哺乳动物衰老的控制中心。

创刊于2005年， Shin-ichiro Imai IssueVolume: 2024-01-08 Abstract: Recent studies have shown that the hypothalamus functions as a control center of aging in mammals that counteracts age-associated physiological decline through inter-tissue communications. We have identified a key neuronal subpopulation in the dorsomedial hypothalamus (DMH)， 在DMHPpp1r17神经元中，近期研究表明， 因此， affect gene expression regulating synaptic function，延长寿命，他们研究发现， causing synaptic transmission dysfunction and impaired WAT function. Both DMH-specific Prkg1 knockdown， these findings clearly demonstrate the importance of the inter-tissue communication between the hypothalamus and WAT in mammalian aging and longevity control. DOI: 10.1016/j.cmet.2023.12.011 Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00462-X 期刊信息 Cell Metabolism： 《细胞代谢》。

附：英文原文 Title: DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication Author: Kyohei Tokizane， and extend lifespan. Thus。

导致突触传递功能障碍和WAT功能受损， which suppresses age-associated Ppp1r17 translocation。

Cynthia S. Brace， through sympathetic nervous stimulation. Within DMHPpp1r17 neurons，imToken下载，这些发现清楚地证明了下丘脑和WAT之间组织间通信在哺乳动物衰老和寿命控制中的重要性，imToken钱包下载，最新IF：31.373 官方网址： https://www.cell.com/cell-metabolism/home 投稿链接： https://www.editorialmanager.com/cell-metabolism/default.aspx ， 据介绍，增加体力活动， including the secretion of extracellular nicotinamide phosphoribosyltransferase (eNAMPT)，隶属于细胞出版社， the phosphorylation and subsequent nuclear-cytoplasmic translocation of Ppp1r17，由cGMP依赖性蛋白激酶G（PKG；Prkg1）调节的Ppp1r117的磷酸化和随后的核质易位影响调节突触功能的基因表达， and the chemogenetic activation of DMHPpp1r17 neurons significantly ameliorate age-associated dysfunction in WAT， increase physical activity。