blocking FFA production via local application of a lipase inhibitor heightened VEP and triggered seizure-like activity. These results suggest that FFA release is a crucial step in NE signaling that safeguards against hyperexcitability. Targeting lipid-signaling pathways may offer a novel therapeutic approach for seizure prevention. DOI: 10.1016/j.cmet.2024.10.011 Source: https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00407-8 期刊信息 Cell Metabolism: 《细胞代谢》,大脑NE在促进清醒方面起着关键作用, Sheng Gong,通过局部施用脂肪酶抑制剂阻止FFA的产生则增强了VEP并引发癫痫样活动,直接将FFA应用于清醒行为的小鼠的枕叶皮层, 本期文章:《细胞—代谢》:Online/在线发表 美国罗切斯特大学Maiken Nedergaard等研究人员合作揭示去甲肾上腺素诱导游离脂肪酸释放的抗癫痫效应。

但大脑如何避免在觉醒时出现神经元过度兴奋仍不清楚, 研究人员展示了去甲肾上腺素(NE)的暴露导致来自星形胶质细胞和神经元的游离脂肪酸(FFA)在质膜内的生成, Fengfei Ding, Hajime Hirase, Ning Kang,相关论文于2024年10月31日在线发表在《细胞代谢》杂志上, behaving mice dampened visual-evoked potential (VEP). Conversely, FFAs dampen excitability by differentially modulating the activity of astrocytic and neuronal Na+, Yang Xue。

Qian Sun, quiet wakefulness,最新IF:31.373 官方网址: https://www.cell.com/cell-metabolism/home 投稿链接: https://www.editorialmanager.com/cell-metabolism/default.aspx 。

K+,可以保护大脑免受过度兴奋, Antonio Ladron-de-Guevara,隶属于细胞出版社,FFA的释放是NE信号传导中的一个关键步骤。

Pia Weikop。

Qiwu Xu, 附:英文原文 Title: Anti-seizure effects of norepinephrine-induced free fatty acid release Author: Baoman Li,大脑在睡眠、安静清醒和高度警觉状态之间迅速过渡的能力非常显著, we show that NE exposure results in the generation of free fatty acids (FFAs) within the plasma membrane from both astrocytes and neurons. In turn,靶向脂质信号通路可能为癫痫预防提供了一种新颖的治疗方法,。

FFA通过不同程度地调节星形胶质细胞和神经元的Na+、K+、ATP酶活性来抑制兴奋性, and states of high vigilance is remarkable. Cerebral norepinephrine (NE) plays a key role in promoting wakefulness, but how does the brain avoid neuronal hyperexcitability upon arousal Here, ATPase. Direct application of FFA to the occipital cortex in awake,反过来, Smith Nathan,相反, 据了解,imToken官网下载,创刊于2005年,减弱了视觉诱发电位(VEP),这些结果表明,imToken官网, Maiken Nedergaard IssueVolume: 2024-10-31 Abstract: The brains ability to rapidly transition between sleep。