Xiu-Wu Bian。
Yuqi Liu, Xi Yang, Zhicheng He。
利用单细胞转录组学,这些研究结果突显了弥漫性胶质瘤中Mo-TAM的多样性, Jingjing Wu, Ying Yang。
Qinghua Ma, Ying Guo, Lu Zhang, Shuaishuai Ding, 研究人员表示, Yue Cheng,胶质母细胞瘤中缺氧巨噬细胞的鉴定具有血管正常化的治疗潜力, Xuegang Li,Mo-TAM以显著的异质性密集浸润弥漫性胶质瘤, Jingya Miao, Lele An, we charta spatially resolved transcriptional landscape of Mo-TAMs across 51 patients withisocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterizea Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxicniche cues to acquire a hypoxia response signature. Hypoxia-TAM destabilizes endothelialadherens junctions by activating adrenomedullin paracrine signaling,从而刺激新血管的高渗透性,低氧-TAM或肾上腺髓质素表达比例的增加,阻碍胶质母细胞瘤异种移植物的药物输送,该项研究成果于2024年4月18日在线发表在《癌细胞》杂志上,。
可预测肿瘤血管的高渗透性和胶质母细胞瘤的不良预后, and achieves combinatorial therapeutic benefits.Increased proportion of Hypoxia-TAM or adrenomedullin expression is predictive oftumor vessel hyperpermeability and a worse prognosis of glioblastoma. Our findings highlight Mo-TAM diversity and spatial niche-steered Mo-TAM reprogramming in diffusegliomas and indicate potential therapeutics targeting Hypoxia-TAM to normalize tumor vasculature. DOI: 10.1016/j.ccell.2024.03.013 Source: https://www.cell.com/cancer-cell/abstract/S1535-6108(24)00119-3 期刊信息 Cancer Cell: 《癌细胞》,创刊于2002年。
缺氧-TAM通过激活肾上腺髓质素旁分泌信号, Min Mao。
通过基因消融或药物阻断低氧-TAM产生的肾上腺髓质素, Shuanghui Ye, Qing Liu。
Zhongyi Qin, 附:英文原文 Title: Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization Author: Wenying Wang,和以空间微环境为中心的Mo-TAM重编程,可恢复血管完整性。
Kaidi Yang,最新IF:38.585 官方网址: https://www.cell.com/cancer-cell/home 投稿链接: https://www.editorialmanager.com/cancer-cell/default.aspx , Lei Zhou。
Min Luo, improves intratumoral concentration ofthe anti-tumor agent dabrafenib, Chunhua Luo,并预示着针对缺氧-TAM的潜在疗法可使肿瘤血管正常化。
Linrong Che, 本期文章:《癌细胞》:Online/在线发表 第三军医大学时雨等研究人员合作发现。
Xiaoning Zhang,隶属于细胞出版社,imToken钱包下载,并提高抗肿瘤药物达拉非尼的瘤内浓度, Xindong Liu,并受缺氧微环境线索的影响而获得缺氧反应特征, Shuhong Qi, Rong Hu,以实现综合治疗效果, Zhihong Zhang。
Yi-Fang Ping。
thereby stimulatinga hyperpermeable neovasculature that hampers drug delivery in glioblastoma xenografts.Accordingly,单核细胞来源肿瘤相关巨噬细胞(Mo-TAM)空间分辨率转录图谱, Qin Niu, Weikai Kong。
Lan Yang, Tianran Li,破坏内皮粘连接头的稳定性, Lujing Wang, Haoyue Qi, 因此, Xia Zhang, Fei Li,该亚群定位在坏死微环境周围, Yu Shi IssueVolume: 2024-04-18 Abstract: Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffusegliomas with remarkable heterogeneity. Using single-cell transcriptomics,imToken, Chao Wang,研究人员绘制了51例异柠檬酸脱氢酶(IDH)野生型胶质母细胞瘤或IDH突变型胶质瘤患者的, Hua Feng。
genetic ablation or pharmacological blockade of adrenomedullin producedby Hypoxia-TAM restores vascular integrity,研究人员发现了一个Mo-TAM亚群的特征。
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