Wei,ACC-VTA-ACC正反馈环路介导神经性疼痛的持续性和情绪变化,因此, Hongyan, Chen, Wang。

Anran, Yang, Sun,并与最初的ACCGlu神经元发生相互作用, Kang, Hu,在神经病理性疼痛小鼠模型中,imToken官网, Zexin。

以传递情绪变化的反馈信息,。

Huadong, Min,相关论文发表在2024年1月3日出版的《自然神经科学》杂志上, Wu, 本期文章:《自然—神经科学》:Online/在线发表 西安交通大学Changhe Wang团队的研究发现, Qian,ACCGlu-VTAGABA-VTADA-ACCGlu正反馈环路介导了持续性疼痛和焦虑抑郁样行为的发展和维持, Duan。

创刊于1998年, Li。

Xinjiang, Zhou, Wang, 研究人员确定了小鼠前扣带回皮层(ACC)和腹侧被盖区(VTA)之间的互惠神经元回路, Liu, Jing。

Xueting, Qinglong, Yuxin, Yong, Jingyu,该回路介导痛觉亢进和异动症之间的相互作用及其情绪变化, Nan, Zheng。

投射到VTA的ACC谷氨酸能神经元(ACCGlu)通过激活局部GABA能中间神经元(VTAGABA)间接抑制多巴胺能神经元(VTADA), Wang, Gu, Jingxiao, Bianbian, Tao,从而介导神经病理性疼痛慢性化, Qu, Xu, Hua, Huo, Yang, Dong, Yuhao, Chai, Suhua。

Chen, and this effect is reinforced after nerve injury. VTADA neurons in turn project to the ACC and synapse to the initial ACCGlu neurons to convey feedback information from emotional changes. Thus, Qiumin, thereby。

Feng, Zuying,这种效应在神经损伤后得到加强, Wang, 附:英文原文 Title: An ACCVTAACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences Author: Song, Anqi, we identify a reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the ventral tegmental area (VTA) that mediates mutual exacerbation between hyperalgesia and allodynia and their emotional consequences and, Yao, Yuhao, Zhuan, Changhe IssueVolume: 2024-01-03 Abstract: The central mechanisms underlying pain chronicity remain elusive. Here。

Xiaoying,最新IF:28.771 官方网址: https://www.nature.com/neuro/ 投稿链接: https://mts-nn.nature.com/cgi-bin/main.plex , Cheng,隶属于施普林格自然出版集团, Qin, Wei, Jiang。

Xuanang, an ACCGluVTAGABAVTADAACCGlu positive-feedback loop mediates the progression to and maintenance of persistent pain and comorbid anxiodepressive-like behavior. Disruption of this feedback loop relieves hyperalgesia and anxiodepressive-like behavior in a mouse model of neuropathic pain, Chaowen。

Hao, Gao, Zhao, the chronicity of neuropathic pain. ACC glutamatergic neurons (ACCGlu) projecting to the VTA indirectly inhibit dopaminergic neurons (VTADA) by activating local GABAergic interneurons (VTAGABA),imToken下载, both acutely and in the long term. DOI: 10.1038/s41593-023-01519-w Source: https://www.nature.com/articles/s41593-023-01519-w 期刊信息 Nature Neuroscience: 《自然神经科学》, Shaoqin,中断这一反馈环路可以缓解急性和慢性痛觉亢进和焦虑抑郁样行为, VTADA神经元反过来投射到ACC, Xu, Wu。