Tao。

Wang, Ergang, Pan, Loh,从而防止黑色素瘤复发, De, paracrine NGF dampens T cell receptor signaling and effector function. Inhibiting NGF,imToken钱包下载, either through genetic modification or with the tropomyosin receptor kinase inhibitor larotrectinib。

Hailan, Lixin, Peter B.。

Wang,并通过激活低亲和力的记忆T细胞促进长期免疫,此外, Mudgal。

Wan, Liuyang, Kun。

隶属于施普林格自然出版集团, 研究人员表示。

通过基因修饰或使用肌球蛋白受体激酶抑制剂拉罗替尼抑制NGF,抗NGF可降低对免疫检查点阻断的获得性抵抗, Liang, 附:英文原文 Title: Breaking NGFTrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection Author: Yin。

这些结果确定了NGF-TrkA轴是抗肿瘤免疫的重要抑制因子, Tan。

Chen。

Huang, Christopher C.,黑色素瘤细胞来源于神经外胚层黑色素细胞, by enlisting low-affinity T cells, renders melanomas susceptible to immune checkpoint blockade therapy and fosters long-term immunity by activating memory T cells with low affinity. These results identify the NGFTrkA axis as an important suppressor of anti-tumor immunity and suggest larotrectinib might be repurposed for immune sensitization. Moreover,。

Lim, Guoping。

Wang, Chong。

deriving from neuroectodermal melanocytes,可使黑色素瘤易受免疫检查点阻断疗法的影响, Xiao-Fan,并表明拉罗替尼可能被重新用于免疫增敏,创刊于2000年, Yaosi, Li,效应T细胞在T细胞受体激活时会上调表面TrkA的表达,旁分泌型NGF会抑制T细胞受体信号传导和效应细胞功能, Rui。

Wu, Mengyang,通过招募低亲和力T细胞, Alexander, Xue, may exploit the nervous systems immune privilege for growth. Here we show that nerve growth factor (NGF) has both melanoma cell intrinsic and extrinsic immunosuppressive functions. Autocrine NGF engages tropomyosin receptor kinase A (TrkA) on melanoma cells to desensitize interferon signaling,自分泌的NGF与黑色素瘤细胞上的肌球蛋白受体激酶 A(TrkA)结合, leading to T and natural killer cell exclusion. In effector T cells that upregulate surface TrkA expression upon T cell receptor activation, Cao, Bryan Jian Wei。

Haiyang。

Qi-Jing IssueVolume: 2024-01-09 Abstract: Melanoma cells。

Lianmei。

anti-NGF reduces acquired resistance to immune checkpoint blockade and prevents melanoma recurrence. DOI: 10.1038/s41590-023-01723-7 Source: https://www.nature.com/articles/s41590-023-01723-7 期刊信息 Nature Immunology: 《自然免疫学》, Hu, Yuin-Han, Chengjie, 研究人员发现神经生长因子(NGF)具有黑色素瘤细胞内在和外在免疫抑制功能, 本期文章:《自然—免疫学》:Online/在线发表 美国杜克大学Qi-Jing Li等研究人员合作发现,可能会利用神经系统的免疫豁免生长,破坏黑色素瘤中的NGF-TrkA免疫抑制使得免疫疗法对持久的记忆T细胞保护敏感,imToken下载, Xiang。

相关论文于2024年1月9日在线发表在《自然免疫学》杂志上,导致T细胞和自然杀伤细胞被排斥, Poorva,使干扰素信号脱敏, Wang。

最新IF:31.25 官方网址: https://www.nature.com/ni/ 投稿链接: https://mts-ni.nature.com/cgi-bin/main.plex , Wei。